DNA

Driven by her fascination with highly repetitive, hard-to-read parts of our DNA, Karen Miga led a coalition of researchers to finish sequencing the human genome after almost two decades.

Genomes hold immense quantities of noncoding DNA. Some of it is essential for life, some seems useless, and some has its own agenda.

New work shows that neurons and other brain cells use DNA double-strand breaks, often associated with cancer, neurodegeneration and aging, to quickly express genes related to learning and memory.

Scientists have reported large DNA structures in some archaea that defy easy categorization.

The DNA of some viruses doesn’t use the same four nucleotide bases found in all other life. New work shows how this exception is possible and hints that it could be more common than we think.

The discovery of a gene shared by two unrelated species of fish is the latest evidence that horizontal gene transfers occur surprisingly often in vertebrates.

Transcription factors that act throughout the genome can arise from mashups of transposable elements inserted into established genes.

New work shows that histones, long treated as boring spools for DNA, sit at the center of the origin story of eukaryotes and continue to play important roles in evolution and disease.

The bizarre genome of the world’s most mysterious flowering plants shows how far parasites will go in stealing, deleting and duplicating DNA.